What paraneoplastic condition is often associated with mastocytosis in dogs?

Mastocytosis in dogs is commonly associated with gastric hyperacidity due to the increased release of histamine from mast cells. Mast cells are a type of immune cell that, when neoplastic (cancerous), can proliferate excessively and release large amounts of histamine. Histamine not only plays a role in allergic reactions but also stimulates the production of gastric acid.

When histamine is overproduced, it leads to increased secretion of gastric acid, resulting in gastric hyperacidity. This condition can cause gastrointestinal symptoms such as ulcers, vomiting, and discomfort. The association of mastocytosis with gastric hyperacidity is a well-documented paraneoplastic syndrome, making it an important consideration when diagnosing and managing dogs with mast cell tumors.