When treating a dog with carprofen for osteoarthritis, which parameter should be monitored to prevent potential toxicity?

Monitoring serum liver enzyme activity is crucial when treating a dog with carprofen for osteoarthritis due to the potential risk of hepatotoxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) like carprofen. Carprofen is metabolized by the liver, and elevated liver enzymes can indicate liver injury or dysfunction, which can lead to serious complications if not addressed. Regular assessment of liver enzyme levels allows for early detection of any adverse effects on the liver, enabling timely intervention either by adjusting the dosage, discontinuing the medication, or switching to an alternative treatment.

The importance of monitoring liver enzyme activity stems from the fact that the liver plays a significant role in drug metabolism, and any pre-existing liver conditions may be exacerbated by medications such as carprofen. By keeping an eye on enzyme levels, veterinarians can safeguard against potential toxic effects, ensuring the treatment remains safe and effective for managing osteoarthritis in dogs.