Which antibiotic is indicated for the treatment of canine pyoderma?

Cephalexin is indicated for the treatment of canine pyoderma primarily because it is a first-generation cephalosporin antibiotic that is effective against the common bacteria associated with skin infections in dogs, particularly Staphylococcus pseudintermedius. This bacterium is often implicated in cases of pyoderma, which is a skin condition characterized by pus formation due to bacterial infection.

Cephalexin possesses good stability in a dog’s gastrointestinal tract and is well-absorbed, making it a reliable choice for treating superficial and deep pyodermas. Its broad-spectrum activity allows it to cover various strains of bacteria that can contribute to skin infections, thus making it a preferred choice among veterinarians.

While the other antibiotics listed may have their uses in different contexts—like amoxicillin for a range of infections, clindamycin for anaerobic infections, and enrofloxacin for more resistant cases—they are not the first-line treatment specifically recommended for canine pyoderma due to factors like the bacteria most commonly involved and efficacy.